Decreased gnrh secretion adult

Sabrina Gill, Julie L. Sharpless, Kimberly Rado, Janet E. Studies of the effects of gonadal steroid negative feedback and age on the hypothalamic-pituitary axis in postmenopausal women PMW have identified significant but inconsistent changes in gonadotropin dynamics. In the current study, we investigated the effect of gonadal steroid replacement and age on overall GnRH secretion estimated by using submaximal GnRH receptor blockade. Percent inhibition of LH was calculated by expressing the difference between the nadir following GnRH antagonist administration and the preantagonist baseline as a percent of the baseline. Physiologic E and P levels were achieved with the appropriate hormone replacement regimens.

GnRH plays an essential role in neuroendocrine control of reproductive function. In mammals, the pattern of gonadotropin secretion includes both pulse and surge phases, which are regulated independently. The pulsatile release of GnRH and LH plays an important role in the development of sexual function and in the normal regulation of the menstrual cycle. The importance of GnRH pulsatility was established in a series of classic studies.

NCBI Bookshelf. Endotext [Internet]. Gonadotropin hormone-releasing hormone GnRH is the key regulator of the reproductive axis.

Although it is known that GH plays an important role in normal growth and development, its influence on the control of gonadotropin secretion is poorly understood. Vehicle-treated animals served as controls. Two experiments were conducted to evaluate the gonadotropin responses to: 1 GnRH in saline in gonad-intact rats and 2 testosterone propionate TP; in oil in castrated rats.